Overview of all possible inputs and how to input them correctly.
To answer what kind of queries one can search on the Home Page, we recommend reading through the Home Page section to fully understand the answer.
This webpage allows you to search your queries. It requires an initial login process to access. Once signed in, you can find your name at the top right corner while your latest query history is logged in the cards below. You can later simply press a card to repeat that search query.
Supported Input:
| Command type | Data Type | Detail | |
|---|---|---|---|
| Text | English query NLP terms (and/or/andnot/similar) can be used to refer proteins/domains/genes"similar X", "similar X and Y", "similar X andnot Y", "similar X or Y" | English words related to existing DNA/RNA/AA sequences | similar cancer, similar coronavirus or rotavirus |
| Sequence | Plain sequence | DNA/RNA/AA sequence | FQTWEEFSRAAEKLYLADPMKVRVVLKYRHVDGNLCIKVTDDLVCLVYRTDQAQDVKKIEKF... |
| ID | External ID List of Database Names: PDB, SWISSPROT, GENBANK, REFSEQ, IEDB, PATENT*Please strictly follow the annotation of Database Names above | Unique ID related to DNA/RNA/AA sequence | SWISSPROT:P35858 |
| FASTA | FASTA record for protein sequences | AA sequence | >seq0 [|Description]FQTWEEFSRAAEKLYLADPMKVRVVLKYRHVDGNLCIKVTDDLVCLVYRTDQAQDVKKIEKF |
| FASTA | FASTA record with technical addition for DNA/RNA sequences>[ID|]Mol Type | Codon start location | Translation table ID | Organism informationSequenceOr alternatively:>[ID|]Mol Type | Codon start location | Translation table ID | Organism information|Sequence | DNA/RNA sequence | >MRNA|2|11|NM_001198823.1 Mus musculus amyloid beta (A4) precursor protein (App), transcript variant 1, mRNAGTCAGTTTCCTCGGCGGCGGGAGGCGAGOr alternatively:>MRNA|2|11|NM_001198823.1 Mus musculus amyloid beta (A4) precursor protein (App), transcript variant 1, mRNA|GTCAGTTTCCTCGGCGGCGGGAGGCGAG |
An example of using plain text to perform a search on retrovirus.
Query of DNA/RNA sequence in FASTA format:
Another novelty of this search bar is its query parsing ability for translation tables in given FASTA records.
When using DNA/RNA sequence to search, it is important that the translation table and starting position are also given to the search query. The query format would be the following:
Input format:
>fasta header
Sequence
Pressing 'Enter' will launch the query, to start a new line press 'Shift+Enter'
QUERY EXPLANATION TAB:
Once the results of a query are retrieved, the way the query was processed can be reviewed. This includes the interpretation of the R&R app over the inserted query, as well as information about the translation that took place in the background (the latter is available only for DNA an RNA sequences).
Click on the “x matches found“ button and the information related to the query explanation are presented:
FASTA File as input:
An additional feature of the Search Bar is its ability to directly receive FASTA file as input, simply uploading it from the local disk. The sequences, together with the additional information contained in the file, are automatically parsed and can displayed on the Search Bar. After the file selection, the Search button needs to be hit, in order to obtain the similar sequences.
Search only on specific datasets.
There is also the possibility to select specific datasets which the search can be performed on, instead of all of them. It is also possible to set a limit on the maximum amount of results returned from each dataset.
This selection can take place on the Home Page, as such.