Epitope Mapping requires structural models as input. Upload existing .PDB models or work from a de novo Alpha Fold model or immunebuilder.
Step 1. Begin by locating the Epitope Mapping icon on your dashboard or application interface.
Step 2. Select your input datasets:
Step 3. Define your input chains - Receptor input chains & Ligand chains:
Define the chains you want to include or exclude from the analysis. This step is particularly useful when working with an existing protein complex model, where multiple chains may be present. By specifying the chains of interest, you can focus your analysis on particular receptor or ligand components, allowing for a more targeted investigation of their interactions. Additionally, excluding irrelevant chains can help streamline the computation process, reduce noise in the results, and enhance the clarity of your findings. Make sure to carefully review the chains in your model to ensure that your selections align with your research objectives.
Do not use comma separation.
Examples:
Using Immubuilder models? Your chains are identified as H or L. Including both: HL
Using PDB models? Most often chains are alphabetical; A,B,C. Including all chains: ABC
Step 4. Provide an experiment name & run the job:
